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Cosmetic Ingredient Hotlist

For assistance on the Ingredient Hotlist, please refer to "How to read the Cosmetic Ingredient Hotlist"

2022

List of Ingredients that are Prohibited for Use in Cosmetic Products

List of Ingredients that are Prohibited for Use in Cosmetic Products:
Ingredient CAS (including but not limited to)table 1 note 1 Synonyms and Related Compounds
(including but not limited to)table 1 note 2
1,2-Epoxybutane 106-88-7  
1,3-Butadiene 106-99-0  
1,3-Dimethylpentylamine and its salts 105-41-9  
11-α-Hydroxypregn-4-ene-3,20-dione and its esters 80-75-1  
1- and 2-Naphthylamines and their salts
  • 134-32-7;
  • 91-59-8
  
1-Butyl-3-(N-crotonoylsulfanilyl) urea 52964-42-8
  • 2-Butenamide, N-[4-[[[(butylamino)carbonyl]amino]sulfonyl]phenyl]-;
  • Crotonoylcarbutamide;
  • Crotulin
1-Methoxy-2,4-diaminobenzene and its salts 615-05-4
  • 2,4-diaminoanisole;
  • Cl 76050
1-Methoxy-2,5-diaminobenzene and their salts 5307-02-8 2,5-diaminoanisole
2-(4-Allyl-2-methoxyphenoxy)-N,N-diethylacetamide and its salts 305-13-5 Estil
2-(4-Methoxybenzyl-N-(2-pyridyl)amino) ethyldimethylamine maleate 59-33-6  
2,3,7,8-Tetrachlorodibenzo-p-dioxin 1746-01-6  
2,3-Dichloro-2-methylbutane 507-45-9 Amylene dichloride
2,4-Diaminophenylethanol and its salts
  • 14572-93-1
  
2,4-Dihydroxy-3-methylbenzaldehyde 6248-20-0  
2-Amino-1,2-bis(4-methoxyphenol) ethanol and its salts 5934-19-0  
2-Amino-4-nitrophenol 99-57-0  
2-Amino-5-nitrophenol 121-88-0  
2-Methoxypropanol 1589-47-5  
2-Methoxypropyl-1-acetate 70657-70-4  
2-Methylheptylamine and its salts 540-43-2
  • 2-Heptanamine, N-methyl-;
  • Methylaminoheptane;
  • Neosupranol;
  • Oenethyl;
  • Pacamine
2-Methyl-m-phenylenediamine 823-40-5 Toluene-2,6-diamine
2-Naphthol 135-19-3  
2-Pentylidenecyclohexanone 25677-40-1  
3-(α-Naphthyl)-4-hydroxycoumarin 39923-41-6  
3,6,10-Trimethyl-3,5,9-undecatrien-2-one 1117-41-5  
3-Diethylaminopropyl cinnamate 538-66-9  
3-Imidazol-4-ylacrylic acid and its ethyl ester
  • 104-98-3;
  • 27538-35-8
  • Urocanic acid;
  • ethyl urocanate
4-(4-Methoxyphenyl)-3-butene-2-one 943-88-4  
4,4'-Dihydroxy-3,3'-(3-methylthiopropylidene) dicoumarin    
4,4'-Bis(dimethylamino)benzophenone 90-94-8 Michler's ketone
4,4'-Isopropylidenediphenol 80-05-7 Bisphenol A
4,6-Dimethyl-8-tert-butylcoumarin 17874-34-9  
4-Amino-2-nitrophenol 119-34-6  
4-Aminosalicylic acid and its salts 65-49-6  
4-Benzyloxyphenol 103-16-2 Monobenzone
4-Ethoxy-m-phenylenediamine and its salts
  • 5862-77-1;
  • 6219-69-8;
  • 68015-98-5;
  • 67801-06-3
  
4-Ethoxyphenol 622-62-8  
4-Methoxy-m-phenylenediamine and its sulfate salts
  • 615-05-4;
  • 39156-41-7;
  • 6219-67-6
  • 2,4-diaminoanisole;
  • 2,4-diaminoanisole sulphate;
  • 1,3-Benzenediamine, 4-methoxy-, sulfate
4-Methoxy-m-phenylenediamine-HCl 614-94-8 2,4-Diaminoanisole dihydrochloride
4-Methyl-m-phenylenediamine and its salts 95-80-7 Toluene-2,4-diamine
4-tert-Butylphenol 98-54-4  
4-tert-Butylpyrocatechol 98-29-3  
5- (α, β-Dibromophenethyl)-5-methylhydantoin 511-75-1 5-(1,2-Dibromo-2-phenylethyl)-5-methylimidazolidine-2,4-dione
5,5'-Diisopropyl-2,2'-dimethylbiphenyl-4,4'-diyl dihypoiodite 552-22-7 Thymol iodide
5,5-Diphenyl-4-imidazolidone 3254-93-1  
5-Methyl-2,3-hexanedione 13706-86-0  
6,10-Dimethyl-3,5,9-undecatrien-2-one 141-10-6  
6-Isopropyl-2-decahydronaphthalenol 34131-99-2  
7-Methoxycoumarin 531-59-9  
Acenocoumarol 152-72-7  
Acetonitrile 75-05-8  
Acetylcholine and its salts 51-84-3 β-acetoxyethyl trimethyl ammonium hydroxide
Acetylsalicylic acid 50-78-2  
Aconitine and its salts 302-27-2  
Aconitum napellus L. leaves, roots and galenical preparations    
Acrylamide monomer 79-06-1  
Adonis vernalis L. and its preparations    
Alkali pentacyanonitrosylferrate (2-)    
Alkyne alcohols and their esters, ethers and salts    
Alloclamide and its salts 5486-77-1  
Allyl isothiocyanate 57-06-7  
Ambenonium salts    
Aminocaproic acid and its salts
  • 1319-82-0;
  • 60-32-2
  
Aminophylline 317-34-0  
Amitriptyline and its salts 50-48-6  
Ammi majus and its galenical preparations    
Amydricaine and its salts 963-07-5
  • Alypine;
  • 1,1-bis(dimethylaminomethyl) propyl benzoate
Amylocaine and its salts 644-26-8  
Anaesthetic effects, substances with    
Analgesics    
Anamirta cocculus L. fruit    
Androgenic effects, substances with
  • 58-22-0;
  • 53-43-0
  • Testosterone;
  • Prasterone
Aniline, its salts and, its halogenated and sulfonated derivatives 62-53-3  
Anthracene oil 120-12-7  
Antiandrogens with steroid structure    
Antibiotics    
Antihistamines    
Antimony and its compounds 7440-36-0  
Apocynum cannabinum L. and its preparations    
Apomorphine and its salts 58-00-4  
Apronalide 528-92-7  
Arecoline 63-75-2  
Aristolochic acid and its salts 313-67-7  
Arsenic and its compounds 7440-38-2  
Atropa belladonna L. and its preparations    
Atropine, its salts and derivatives 51-55-8  
Azacyclonol and its salts 115-46-8  
Azamethonium salts    
Barbiturates    
Basic Violet 1 8004-87-3 CI 42535
Basic Violet 10 81-88-9
  • CI 45170;
  • Rhodamine B
Basic Violet 3 548-62-9
  • CI 42555;
  • CI 42555:1;
  • CI 42555:2
Bemegride 64-65-3  
Benactyzine 302-40-9  
Bendroflumethiazide and its derivatives 73-48-3  
Benzatropine and its salts 86-13-5  
Benzazepines    
Benzene 71-43-2  
Benzidine 92-87-5  
Benzilonium bromide 1050-48-2  
Benzimidazol-2(3H)-one 615-16-7
  • 2H-Benzimidazol-2-one, 1,3-dihydro-;
  • N,N'-(1,2-Phenyleneurea)
Benzodiazepines    
Benzyl chloride 100-44-7  
Benzyl cyanide 140-29-4  
Benzylidene acetone 122-57-6  
Beryllium and its compounds 7440-41-7  
Betoxycaine and its salts 3818-62-0  
Bietamiverine 479-81-2  
Biphenamine and its salts 3572-52-9  
Bispyrithione 3696-28-4  
Bithionol 97-18-7  
Bovine tissues and ingredients derived from the skull, brain, trigeminal ganglia, eyes, spinal cord, and dorsal root ganglia of cattle aged 30 months or older and the small intestine and tonsils of cattle of all ages. This prohibition does not apply to tallow derivatives, or to gelatin, collagen and hydrolyzed proteins prepared from bovine hides and skins    
Bretylium tosilate 61-75-6  
Bromates 7789-38-0; 7758-01-2 Sodium bromate; Potassium bromate
Bromine, elemental 7726-95-6  
Bromisoval 496-67-3  
Brompheniramine and its salts 86-22-6  
Butanilicaine and its salts 3785-21-5  
Butopiprine and its salts 55837-15-5  
Cadmium and its compounds 7440-43-9  
Cannabis, as defined in subsection 2(1) of the Cannabis Act (see the Cannabis Exemption (Food and Drugs Act) Regulations for details)
13956-29-1; ‎521-35-7; ‎1972-08-3 Tetrahydrocannabinol; delta-9-tetrahydrocannabinol; Cannabidiol; Cannabinol; Cannabis Sativa Flower Extract; Cannabis Sativa Flower/Leaf/Stem Extract
Cantharides, Cantharidin and Cantharis vesicatoria
  • 92457-17-5;
  • 56-25-7;
  • 80558-50-5
  
Captan 133-06-2 N-(trichloromethylthio)-4-cyclohexene-1,2-dicarboximide)
Captodiame 486-17-9  
Caramiphen and its salts
  • 77-22-5;
  • 125-85-9
  
Carbazole, nitroderivatives of 86-74-8  
Carbon disulfide 75-15-0  
Carbon tetrachloride 56-23-5  
Carbromal 77-65-6  
Carbutamide 339-43-5  
Carisoprodol 78-44-4  
Cephaeline and its salts 483-17-0  
Cephaelis ipecacuanha Brot. and related species, roots, powder, and galenical preparations    
Chenopodium ambrosioides essential oil 8006-99-3  
Chloral hydrate 302-17-0  
Chloramine T and related compounds
  • 127-65-1;
  • 7080-50-4;
  • 144-86-5
  • Chloramine T trihydrate;
  • N-Chloro-p-toluenesulfonamide
Chlorine 7782-50-5  
Chlormethine and its salts 51-75-2  
Chlormezanone 80-77-3  
Chloroacetamide 79-07-2  
Chloroethane 75-00-3  
Chloroform 67-66-3  
Chlorophacinone 3691-35-8 2-[2-(4-chlorophenyl)-2-phenylacetyl]indan-1,3-dione
Chlorphenoxamine 77-38-3  
Chlorpropamide 94-20-2  
Chlorprothixene and its salts 113-59-7  
Chlortalidone 77-36-1  
Chlorzoxazone 95-25-0  
Choline salts and their esters 62-49-7  
Chromic acid and its salts
  • 7738-94-5;
  • 13530-68-2
  
Chromium 7440-47-3  
Chrysoidine citrate hydrochloride 5909-04-6 2,4-Diaminoazobenzene hydrochloride citrate
CI 12120 2425-85-6 Pigment red 3
CI 12140 3118-97-6  
CI 13065 587-98-4  
CI 42640 1694-09-3  
Cinchocaine and its salts 85-79-0  
Cinchophen, its salts, derivatives and salts of these derivatives 132-60-5  
Claviceps purpurea Tul., its alkaloids and galenical preparations    
Clobetasone 54063-32-0  
Clofenamide 671-95-4  
Clofenotane 50-29-3 DDT
Clostridium botulinum    
Coal tars crude and refined 8007-45-2  
Cobalt benzenesulfonate    
Colchicine, its salts and derivatives 64-86-8  
Colchicoside and its derivatives 477-29-2  
Colchicum autumnale L. and its galenical preparations    
Coniferyl alcohol except for naturally occurring in plant extracts 458-35-5 4-hydroxy-3-methoxycinnamyl alcohol; Gamma-hydroxyisoeugenol
Coniine 458-88-8  
Conium maculatum L. fruit, powder and galenical preparations 85116-75-2  
Convallatoxin 508-75-8  
Coumetarol 4366-18-1  
Creosote
  • 8021-39-4;
  • 8001-58-9
  • Coal tar creosote;
  • wood creosote
Crimidine 535-89-7 2-chloro-6-methylpyrimidin-4-yldimethylamine
Croton tiglium oil 8001-28-3  
Curare 8063-06-7  
Curarine 22260-42-0  
Curarizants, synthetic    
Cyclarbamate 5779-54-4  
Cyclizine and its salts 82-92-8  
Cyclocoumarol 518-20-7  
Cyclomenol and its salts 5591-47-9  
Cyclophosphamide and its salts 50-18-0  
Datura stramonium L. and its galenical preparations
  • 84696-08-2;
  • 8063-18-1;
  • 89998-22-1
  
Deanol aceglumate 3342-61-8  
Decamethylenebis (trimethylammonium) salts
  • 541-22-0;
  • 3198-38-7;
  • 1420-40-2
  • Decamethonium bromide;
  • Decamethonium dichloride;
  • Decamethonium iodide
Dextromethorphan and its salts 125-71-3  
Dextropropoxyphene 469-62-5  
Dialkanolamines, secondary
  • 111-42-2;
  • 110-97-4
  • Diethanolamine (DEA);
  • Diisopropanolamine (DIPA)
Dibromosalicylanilides
  • 24556-64-7;
  • 87-12-7;
  • 2577-72-2
  
Dichloroethanes
  • 1300-21-6;
  • 107-06-2
 Ethylene chlorides
Dichloroethylenes
  • 25323-30-2;
  • 540-59-0;
  • 75-35-4;
  • 156-59-2;
  • 156-60-5
 Acetylene chlorides
Dichlorosalicylanilides
  • 147-98-4;
  • 4214-48-6
  
Dicoumarol 66-76-2  
Diethyl 4-nitrophenyl phosphate 311-45-5  
Diethyl maleate 141-05-9  
Diethyl sulfate 64-67-5  
Diethyl toluamide 134-62-3 DEET
Diethylhexyl phthalate 117-81-7 DEHP
Difencloxazine 5617-26-5  
Digitaline 71-63-6  
Digitalis purpurea L., all heterosides of    
Dihydrotachysterol 67-96-9  
Dimethoxane 828-00-2 2,6-dimethyl-1,3-dioxan-4-yl acetate
Dimethyl citraconate 617-54-9  
Dimethyl sulfate 77-78-1  
Dimethyl sulfoxide 67-68-5 DMSO
Dimethylamine 124-40-3  
Dimethylformamide 68-12-2  
Dimevamide and its salts 60-46-8  
Dinitrophenol isomers 25550-58-7  
Dioxane 123-91-1 1,4-dioxane
Dioxethedrin and its salts 497-75-6  
Diphenhydramine and its salts 58-73-1  
Diphenoxylate hydrochloride 3810-80-8  
Diphenylamine 122-39-4  
Diphenylpyraline and its salts 147-20-6  
Doxylamine and its salts 469-21-6  
Emetine, its salts and derivatives 483-18-1  
Endrin 72-20-8  
Ephedrine and its salts 299-42-3  
Epichlorohydrin 106-89-8 Oxirane, chloromethyl
Epinephrine 51-43-4  
Eserine and its salts 57-47-6  
Estradiol 50-28-2  
Estrogens    
Estrone 53-16-7  
Ethinylestradiol 57-63-6  
Ethionamide 536-33-4  
Ethoheptazine and its salts 77-15-6  
Ethoxyethanol 110-80-5  
Ethoxyethanol acetate 111-15-9  
Ethyl biscoumacetate and salts of the acid 548-00-5  
Ethyl PABA 94-09-7
  • Benzocaine;
  • 4-Aminobenzoic Acid, Ethyl Ester
Ethylene oxide 75-21-8  
Ethylenediamine 107-15-3  
Ethylphenacemide 90-49-3  
Fenadiazole 1008-65-7  
Fenozolone 15302-16-6  
Fenyramidol 553-69-5  
Ficus carica leaf absolute 68916-52-9  
Fluanisone 1480-19-9  
Fluoresone 2924-67-6  
Fluorouracil 51-21-8  
Furazolidone 67-45-8  
Furfuryltrimethyl ammonium salts    
Galantamine 357-70-0  
Gallamine triethiodide 65-29-2  
Glucocorticoids 1524-88-5  
Glutarimide and its salts 1121-89-7  
Glutethimide and its salts 77-21-4  
Glycyclamide 664-95-9  
Gold salts
  • 16903-35-8;
  • 105883-47-4
  • Gold chloride HCl;
  • Gold acetylmethionate;
  • Gold aspartate/glutamate
Guaifenesin 93-14-1  
Guanethidine and its salts 55-65-2  
Haloperidol 52-86-8  
HC Blue No. 4 158571-57-4  
HC Blue No. 5 68478-64-8; 158571-58-5  
Hexachloroethane 67-72-1  
Hexachlorophene 70-30-4 2,2'-dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane
Hexaethyl tetraphosphate 757-58-4  
Hexamethonium salts    
Hexapropymate 358-52-1  
Hydrastine and its salts 118-08-1  
Hydrastinine and its salts 6592-85-4  
Hydrazides and their salts
  • 54-85-3;
  • 1071-93-8;
  • 123-33-1
  
Hydrazine, its derivatives and their salts 302-01-2  
Hydroabietyl alcohol
  • 13393-93-6;
  • 26266-77-3
  
Hydrofluoric acid, its normal salts, its complexes and hydrofluorides 7664-39-3  
Hydrogen cyanide and its salts 74-90-8  
Hydroxyzine 68-88-2  
Hyoscine, its salts and derivatives 51-34-3  
Hyoscyamine its salts and derivatives 101-31-5  
Hyoscyamus niger L. leaves, seeds, powder, and galenical preparations    
Imperatorin 482-44-0  
Inproquone 436-40-8  
Inula helenium oil 97676-35-2  
Iodine 7553-56-2  
Isocarboxazide 59-63-2  
Isodrin 465-73-6  
Isometheptene and its salts 503-01-5  
Isophorone 78-59-1  
Isoprenaline 7683-59-2  
Isoprene monomer 78-79-5 1,3-butadiene, 2-methyl
Isopropamide salts   N-(3-carbamoyl-3,3-diphenylpropyl)-N,N-diisopropylmethylammonium)
Isosorbide dinitrate 87-33-2  
Juniperus sabina L. leaves, essential oil and galenical preparations 68916-94-9  
Laurus nobilis L., oil from the seeds of 8007-48-5  
Lead acetate 301-04-2  
Lead and its compounds 7439-92-1  
Levophacetoperane and its salts 24558-01-8  
Lidocaine 137-58-6  
Lindane 58-89-9  
Lobelia inflata L. and its galenical preparations    
Lobeline and its salts 90-69-7  
Lysergide and its salts 50-37-3  
Malononitrile 109-77-3  
Mannomustine and its salts 576-68-1  
Mecamylamine 60-40-2  
Mefeclorazine and its salts 1243-33-0  
Mephenesin and its esters 59-47-2  
Meprobamate 57-53-4  
Mercury and its compounds
  • 7439-97-6;
  • 21908-53-2;
  • 62-38-4;
  • 94-43-9;
  • 102-98-7;
  • 6273-99-0;
  • 54-64-8
  • Mercuric oxide;
  • Phenyl mercuric acetate;
  • Phenyl mercuric benzoate;
  • Phenyl mercuric borate;
  • Thimerosal
Mescaline and its salts 54-04-6 3,4,5-trimethoxyphenethylamine
Metaldehyde 9002-91-9  
Metamfepramone and its salts 15351-09-4  
Metethoheptazine and its salts 509-84-2  
Metformin and its salts 657-24-9  
Methapyrilene and its salts 91-80-5  
Metheptazine and its salts 469-78-3  
Methocarbamol 532-03-6  
Methotrexate 59-05-2  
Methoxydiglycol 111-77-3
  • Diethylene glycol monomethyl ether;
  • DEGME
Methoxyethanol 109-86-4  
Methoxyethanol acetate 110-49-6  
Methyl methacrylate monomer 80-62-6  
Methyloxirane monomer 75-56-9 Propylene oxide
Methylphenidate and its salts 113-45-1  
Methyl-trans-2-butenoate 623-43-8  
Methyprylon and its salts 125-64-4  
Metyrapone 54-36-4  
Minoxidil, its salts and derivatives 38304-91-5  
Mixed cresols and derivatives 1319-77-3  
Mofebutazone 2210-63-1  
Morpholine and its salts 110-91-8  
Musk ambrette 83-66-9 4-tert-butyl-3-methoxy-2,6-dinitrotoluene
Musk tibetene 145-39-1 1-tert-butyl-3,4,5-trimethyl-2,6-dinitrobenzene
N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts 126-85-2 Nitrogen mustard N-oxide
N-5-Chlorobenzoxazol-2-ylacetamide and its salts 35783-57-4  
Nalorphine, its salts and ethers 62-67-9  
Naphazoline and its salts 835-31-4  
Naphthalene 91-20-3  
Narcotics, natural and synthetic    
Neodymium and its salts 7440-00-8  
Neostigmine and its salts 59-99-4  
Nerium oleander, its extracts and its glycosides
  • 465-16-7;
  • 84929-39-5
  • Oleandrin;
  • Neriifolin;
  • Thevetin A;
  • Thevetin B
Nicotine and its salts 54-11-5  
Nitrites, amyl    
Nitrites, inorganic, except sodium nitrite 14797-65-0  
Nitrobenzene 98-95-3  
Nitrocresols and their alkali metal salts
  • 12167-20-3;
  • 119-33-5;
  • 4920-77-8;
  • 2042-14-0;
  • 2581-34-2;
  • 5428-54-6;
  • 700-38-9;
  • 2666-76-4
  • 2-Nitro-4-cresol;
  • 2-Nitro-m-cresol;
  • 3-Nitro-p-cresol;
  • 4-Nitro-m-cresol;
  • 4-Nitro-o-cresol;
  • 5-Nitro-o-cresol;
  • 6-Nitro-m-cresol;
  • Sodium 4-nitro-m-cresolate
Nitrofurantoin 67-20-9  
Nitroglycerin 55-63-0  
Nitrosamines
  • 64091-91-4;
  • 35576-91-1;
  • 930-55-2;
  • 100-75-4;
  • 10595-95-6;
  • 59-89-2;
  • 621-64-7;
  • 924-16-3;
  • 55-18-5;
  • 1116-54-7;
  • 62-75-9
 N-nitrosodiethanolamine
Nitrostilbenes, their homologues and their derivatives    
Nitroxoline and its salts 4008-48-4  
Noradrenaline and its salts 51-41-2  
Noscapine and its salts 128-62-1  
O,O'-Diacetyl-N-allyl-N-normorphine 2748-74-5 Diacetylnalorphine
O-Alkyldithiocarbonic acids, salts of
  • 140-93-2;
  • 140-92-1;
  • 1000-90-4
  
Octamoxin and its salts 4684-87-1  
Octamylamine and its salts 502-59-0  
Octodrine and its salts 543-82-8  
o-Phenylenediamine and its salts 95-54-5  
Oxanamide and its derivatives 126-93-2  
Oxpheneridine and its salts 546-32-7  
PABA, esters of; with a free amino group   4-aminobenzoic acid
Paramethasone 53-33-8  
Parathion 56-38-2 O,O'-diethyl O-4-nitrophenyl phosphorothioate
Parethoxycaine and its salts 94-23-5  
Pelletierine and its salts 2858-66-4  
Pemoline and its salts 2152-34-3  
Pentachloroethane 76-01-7  
Pentaerythrityl tetranitrate 78-11-5  
Pentamethonium salts    
Pentyl dimethyl PABA, mixed isomers 14779-78-3 Amyl 4-dimethylaminobenzoate
Petrichloral 78-12-6  
Phenacemide 63-98-9  
Phenaglycodol 79-93-6  
Phenetamine 3590-16-7 Feclemine
Phenindione 83-12-5  
Phenmetrazine, its derivatives and salts 134-49-6  
Phenol 108-95-2  
Phenolphthalein 77-09-8  
Phenothiazine and its compounds 92-84-2  
Phenprobamate 673-31-4  
Phenprocoumon 435-97-2  
Phenylbutazone 50-33-9  
Pheromones    
Phosphorus and metal phosphides 7723-14-0  
Physostigma venenosum Balf.    
Phytolacca spp. and their preparations 84961-56-8  
Picric acid 88-89-1  
Picrotoxin 124-87-8  
Pigment Orange 5 and its lakes, pigments and salts 3468-63-1 CI 12075
Pigment Red 53 2092-56-0 CI 15585
Pilocarpine and its salts 92-13-7  
Pilocarpus jaborandi Holmes and its galenical preparations    
Pipazetate and its salts 2167-85-3  
Piper methysticum extract 9000-38-8 kava kava
Pipradrol and its salts 467-60-7  
Piprocurarium salts    
Poldine methyl sulfate 545-80-2  
Pramocaine 140-65-8  
Probenecid 57-66-9  
Procainamide, its salts and derivatives 51-06-9  
Progestogens    
Propatylnitrate 2921-92-8  
Propyphenazone 479-92-5  
Prostaglandins, their salts and derivatives and their analogs
  • 745-65-3;
  • 155206-00-1;
  • 40665-92-7;
  • 363-24-6;
  • 35121-78-9;
  • 40666-16-8;
  • 130209-82-4;
  • 59122-46-2;
  • 209860-87-7;
  • 157283-68-6;
  • 81846-19-7;
  • 120373-36-6;
  • 130209-76-6;
  • 1005193-64-5;
  • 157283-66-4
  • Alprostadil;
  • Bimatoprost;
  • Cloprostenol;
  • Dinoprostone;
  • Epoprostenol;
  • Fluprostenol;
  • Latanoprost;
  • Misoprostol;
  • Tafluprost;
  • Travoprost;
  • Treprostinil;
  • Unoprostone;
  • Dehydrolatanoprost;
  • Ethyl Travoprostamide;
  • Trifluoromethyl Dechloro Ethylprostenolamide;
  • Isopropyl Phenylhydroxypentene Dihydroxycyclopentylheptenate;
  • Isopropyl Cloprostenate
Prunus laurocerasus L.    
Psilocybine 520-52-5  
Pueraria mirifica    
Pyrethrum album L. and its galenical preparations    
Pyrocatechol 120-80-9 Catechol
Pyrogallol 87-66-1  
Radioactive substances    
Rauwolfia serpentina alkaloids and their salts    
Retinoic Acid and its salts
  • 302-79-4;
  • 4759-48-2
 Tretinoin; cis-Retinoic Acid; all-trans-retinoic acid
Safrole, except when naturally occurring in plant extracts 94-59-7  
Schoenocaulon officinale Lind. seeds and galenical preparations    
Selenium and its compounds 7782-49-2 Excluding selenium sulfide (7488-56-4)
Sodium hexacyclonate 7009-49-6  
Sodium pyrithione 3811-73-2  
Solanum nigrum L. and its galenical preparations    
Solvent Blue 35 17354-14-2 CI 61554
Solvent Red 24 85-83-6 CI 26105
Solvent Red 49:1 6373-07-5
  • CI 45170:1;
  • Rhodamine B-Stearate
Sparteine and its salts 90-39-1  
Spironolactone 52-01-7  
Steroids    
Strontium nitrite 13470-06-9  
Strontium polycarboxylate    
Strophantines, their aglucones and derivatives 11005-63-3  
Strophantus spp. and their galenical preparations    
Strychnine and its salts 57-24-9  
Strychnos spp. and their galenical preparations    
Succinonitrile 110-61-2  
Sulfinpyrazone 57-96-5  
Sulfonamides and their salts obtained by substitution of one or more H-atoms of the -NH2 groups
  • 63-74-1;
  • 10103-15-8;
  • 6101-31-1;
  • 723-46-6
  
Sultiame 61-56-3  
Sympathicomimetic amines    
Symphytum spp., with the exception of Symphytum officinale   Comfrey
Tefazoline and its salts 1082-56-0  
Tellurium and its compounds 13494-80-9  
Tetrabenazine and its salts 58-46-8  
Tetrabromosalicylanilides    
Tetracain and its salts 94-24-6  
Tetrachloroethylene 127-18-4  
Tetrachlorosalicylanilides    
Tetraethyl pyrophosphate 107-49-3  
Tetrahydrozoline and its salts 84-22-0  
Tetrylammonium bromide 71-91-0  
Thalidomide and its salts 50-35-1  
Thallium and its compounds 7440-28-0  
Theophylline 58-55-9  
Thevetia neriifolia 90147-54-9
  • Yellow oleander;
  • Thevetia peruviana;
  • Thevetia nereifolia;
  • Cascabela thevetia;
  • Cerbera thevetia
Thiamazole 60-56-0  
Thimerosal 54-64-8 See "Mercury and its compounds"
Thiotepa 52-24-4  
Thiourea and its derivatives 62-56-6  
Thyropropic acid and its salts 51-26-3  
Thyrothricine 1404-88-2 Tryothricin
Tiratricol
  • 51-24-1;
  • 1477-04-9
  
Tolboxane 2430-48-8  
Tolbutamide 64-77-7  
Tolnaftate 2398-96-1  
Toluene Diisocyanates
  • 584-84-9;
  • 91-08-7;
  • 26471-62-5
  • TDIs;
  • 2,4-diisocyanato-1-methyl-benzene (2,4-toluene diisocyanate);
  • 2,6-diisocyanato-1-methyl-benzene (2,6 toluene diisocyanate);
  • 1,3-diisocyanatomethyl-benzene (mixed isomers of toluene diisocyanate)
Toluidines, their isomers, salts and halogenated and sulfonated derivatives except 4-hydroxy-2-nitro-toluidine and hydroxyethyl-2-nitro-p-toluidine
  • 26915-12-8;
  • 95-53-4
  
Toxins    
trans-2-Heptenal 18829-55-5  
Tranylcypromine and its salts 155-09-9  
Tretamine 51-18-3  
Triamterene and its salts 396-01-0  
Tribromoethanol 75-80-9  
Tribromosalicylanilide 1322-38-9  
Trichlormethine and its salts 817-09-4  
Trichloroacetic acid 76-03-9  
Trichloronitromethane 76-06-2 Chloropicrine
Tricresyl phosphate 1330-78-5 Tritolyl phosphate
Trifluperidol 749-13-3  
Triparanol 78-41-1  
Tripelennamine 91-81-6  
Tuaminoheptane, its isomers and salts 123-82-0  
Urginea scilla Stern. and its galenical preparations    
Vaccines    
Valnoctamide 4171-13-5  
Veratrine, its salts and galenical preparations 62-59-9  
Veratrum spp. and their preparations    
Versalide 88-29-9  
Vinyl chloride monomer 75-01-4  
Warfarin and its salts 81-81-2  
Xanthinol 2530-97-4  
Xylidines, their isomers, salts, halogenated and sulfonated derivatives 1300-73-8  
Xylometazoline and its salts 526-36-3  
Yohimbine and its salts 146-48-5  
Zoxazolamine 61-80-3  
α-Methylanisalacetone 104-27-8 1-(4-methoxyphenyl)-1-pentene-3-one
α-Santonin 481-06-1  
β-Eucaine 500-34-5  

Table 1 Notes

Table 1 note 1

Cells in this column are left blank when the substance does not have a known CAS.

Return to table 1 note 1 referrer

Table 1 note 2

Cells in this column are left blank when no synonyms or related compounds are provided for the entry.

Return to table 1 note 2 referrer
 

List of Ingredients that are Restricted for Use in Cosmetic Products

The following ingredients are only permitted in cosmetic products under the conditions of use specified below:

Warnings and cautionary statements must appear on the label in both English and French.

List of Ingredients that are Restricted for Use in Cosmetic Products:
Ingredient Information Restrictions
Chemical CAS (including but not limited to)table 2 note 1 Synonyms and Related Compounds
(including but not limited to)table 2 note 2		 Conditions of Use by product typetable 2 note 3 Maximum Concentration Permittedtable 2 note 4 Warnings and Cautionary Statements:
(to the effect of)table 2 note 5
1-Naphthol, and its salts 90-15-3   a) In Hair dyes as an oxidizing colouring agent a) 2%  
b) In combination with hydrogen peroxide b) 1%
2-Bromo-2-nitropropane-1,3-diol 52-51-7   a) Not permitted in cosmetics that contain amines or amides.    
b) Other cosmetics b) 0.1%
5-Bromo-5-nitro-1,3-dioxane 30007-47-7   a) Not permitted in cosmetics that contain amines or amides.    
b) Other cosmetics b) 0.1%
7,11-Dimethyl-4,6,10-dodecatrien-3-one 26651-96-7     2% as an impurity in methylionones  
8-Hydroxyquinoline and its sulfate
  • 148-24-3;
  • 134-31-6
  • 8-Hydroxyquinoline sulfate;
  • Oxyquinoline;
  • Oxyquinoline Sulfate
 a) As stabilizers for hydrogen peroxide in rinse-off hair products a) 0.3%  
b) As stabilizers for hydrogen peroxide in leave-on hair products b) 0.03%
Alkali earth metal sulfides
  • 21109-95-5;
  • 20548-54-3;
  • 12032-36-9;
  • 1314-96-1
  • Barium sulfide;
  • Calcium sulfide;
  • Magnesium sulfide;
  • Strontium sulfide
 In hair removal (depilatory) products 6% as sulfur  
Alkali sulfides
  • 12136-58-2;
  • 1312-73-8;
  • 1313-82-2
  • Lithium sulfide;
  • Potassium sulfide;
  • Sodium sulfide
 In hair removal (depilatory) products 2% as sulfur  
Alpha-hydroxy acids
  • 77-92-9;
  • 79-14-1;
  • 50-21-5;
  • 133-37-9;
  • 6915-15-7;
  • 79-33-4;
  • 5949-29-1;
  • 617-73-2;
  • 90-64-2;
  • 35249-89-9
  • Citric acid;
  • Glycolic acid;
  • Lactic acid;
  • Malic acid;
  • Mandelic acid;
  • Tartaric Acid;
  • Ammonium glycolate;
  • Glycolic acid + ammonium glycolate;
  • Alpha-hydroxyethanoic acid + ammonium alpha-hydroxyethanoate;
  • Alpha-hydroxyoctanoic acid;
  • Alpha-hydroxycaprylic Acid;
  • Hydroxycaprylic Acid;
  • Mixed fruit acid;
  • Triple fruit acid;
  • Tri-alpha hydroxy fruit acids;
  • Alpha hydroxy and botanical complex;
  • L-alpha hydroxy acid;
  • Glycomer in cross-linked fatty acids alpha nutrium.
 a) All skin products containing AHAs at concentrations equal to or greater than 3%   a) "Use only as directed.",
"Avoid contact with the eyes.",
"If irritation persists, discontinue use and consult a physician.",
"It is recommended that prior to exposure to the sun, users cover areas where AHAs have been applied with sunscreen.",
"Contact of the product with the skin must be of limited frequency or duration."
b) Products intended for consumer use: Manufacturer must provide Health Canada with pH levels. b) 10% with a pH equal to or greater than 3.5  
c) Products for professional use:

Manufacturer must provide Health Canada with evidence of safety including:

  1. pH levels
  2. AHA concentrations
  3. Directions for use
  4. Clinical studies demonstrating minimal skin irritation
 c) Between 10% and 30% or a pH between 3.0 to 3.5  
d) Products intended to be diluted in bath water may contain levels of citric acid exceeding 10%.    
Aluminum chloride 7446-70-0;
7784-13-6		   a) Deodorants and antiperspirants containing aluminum chloride are not permitted in aerosol dispensers.    
b) Not permitted in combination with aluminum chlorohydrate or its associated complexes or aluminum zirconium complexes    
c) Deodorants and antiperspirants containing aluminum chloride must be in the form of an aqueous solution. c) 15% calculated as aluminum chloride hexahydrate c) "Discontinue use if rash or irritation occurs."
"Do not use on broken skin."
Aluminum chlorohydrate and its associated complexes
  • 12042-91-0;
  • 1327-41-9;
  • 173762-81-7;
  • 173762-82-8;
  • 10284-64-7;
  • 173720-80-4;
  • 180324-83-8;
  • 11097-68-0;
  • 173763-15-0;
  • 242812-86-8;
  • 173763-16-1;
  • 245090-60-2
  • Aluminum chlorohydrate;
  • Aluminum chlorohydrex PEG;
  • Aluminum chlorohydrex PG;
  • Aluminum dichlorohydrate;
  • Aluminum dichlorohydrex PEG;
  • Aluminum dichlorohydrex PG;
  • Aluminum sesquichlorohydrate;
  • Aluminum sesquichlorohydrex PEG;
  • Aluminum sesquichlorohydrex PG
 a) Not permitted in combination with aluminum chloride, other aluminum chlorohydrate complexes or aluminum zirconium complexes.    
b) Deodorants and antiperspirants b,c) 25% (calculated as the anhydrous form). b) "Discontinue use if rash or irritation occurs."
"Do not use on broken skin."
c) Deodorants and antiperspirants in aerosol dispensers c) "Discontinue use if rash or irritation occurs."
"Do not use on broken skin."
"Keep away from face to avoid inhalation and spraying in the eyes."
"Keep out of reach of children."
Aluminum zirconium complexes
  • 98106-55-9;
  • 174514-58-0;
  • 173762-83-9;
  • 98106-54-8;
  • 125913-22-6;
  • 57158-29-9;
  • 98106-52-6;
  • 90604-80-1;
  • 134910-86-4;
  • 246867-10-7;
  • 235433-35-9;
  • 98106-53-7;
  • 134375-99-8
  • Aluminum zirconium octachlorohydrate;
  • Aluminum zirconium octachlorohydrex GLY;
  • Aluminum zirconium pentachlorohydrate;
  • Aluminum zirconium pentachlorohydrex GLY;
  • Aluminum zirconium tetrachlorohydrate;
  • Aluminum zirconium tetrachlorohydrex GLY;
  • Aluminum zirconium tetrachlorohydrex PEG;
  • Aluminum zirconium tetrachlorohydrex PG;
  • Aluminum zirconium trichlorohydrate;
  • Aluminum zirconium trichlorohydrex GLY
 a) Not permitted in deodorants and antiperspirants in aerosol dispensers.    
b) Not permitted in combination with aluminum chloride, aluminum chlorohydrate or its associated complexes or other aluminum zirconium complexes.    
c) Other cosmetics c) 20% (calculated as the anhydrous form) c) "Discontinue use if rash or irritation occurs."
"Do not use on broken skin."
Azelaic acid and its salts
  • 123-99-9;
  • 52457-54-2;
  • 132499-85-5;
  • 17265-13-3;
  • 27825-99-6
  • Nonanedioic acid;
  • Disodium Azelate;
  • Dipotassium Azelate
   14%  
Barium salts
  • 21109-95-5;
  • 7727-43-7
   Permitted only as barium sulfide in hair removal products (see "Alkali earth metal sulfides"), as barium sulfate, or as a colouring agent or lake for preparation of other colouring agents.    
Benzalkonium chloride
  • 8001-54-5;
  • 61789-71-7;
  • 68391-01-5;
  • 68424-85-1
  • Alkyl(C12-C18)benzyldimethylammonium chloride;
  • Alkyl(C12-16)dimethylbenzylammonium chloride
 a) As a preservative (i.e. benzalkonium chloride with chain lengths ≤ 14 C). a) 0.1%  
b) As a conditioning agent in rinse-off hair care products, (i.e. benzalkonium chloride with chain lengths ≥ 16 C). b) 3% b) All products containing more than 0.1%: "Avoid contact with eyes."
Benzethonium chloride 121-54-0   a) Not permitted in products to be applied to mucous membranes.    
b) Leave-on products b) 0.2%
c) Rinse-off products c) 0.3%
Benzoyl peroxide 94-36-0   a) Not permitted in products to be applied to the skin.    
b) Products to be applied to the fingernails or in hair dyes b) 10% as a catalyst
Boric acid and its salts
  • 10043-35-3;
  • 11113-50-1;
  • 10377-81-8;
  • 68130-12-1;
  • 26038-90-4;
  • 68003-13-4;
  • 10192-46-8;
  • 1332-07-6;
  • 22694-75-3;
  • 27522-09-4;
  • 13703-82-7;
  • 12007-62-4;
  • 1333-73-9;
  • 13840-56-7;
  • 7775-19-1;
  • 1330-43-4;
  • 1303-96-4
  • MEA borate;
  • MIPA borate;
  • Potassium borate;
  • Zinc Borate;
  • Ammonium borate;
  • Magnesium borate;
  • Borax;
  • Sodium borate;
  • Sodium tetraborate;
  • Sodium tetraborate decahydrate
 a) As a pH adjuster a) 0.1%  
b) Other cosmetics b) 5% b) "Do not use on broken or abraded skin, not to be used by children under three years of age."
Brucine 357-57-3     0.1%  
Butane 106-97-8     0.1% w/w of 1,3-butadiene (106-99-0)  
Butoxyethanol 111-76-2   Permitted in hair dyes and nail products only. 10%  
Calcium peroxide 1305-79-9 Calcium dioxide See "Peroxide and peroxide-generating compounds".    
Camphor 76-22-2     3%  
Cannabis spp. (hemp) derivatives or a product made from those derivatives that are exempt from the application of the Cannabis Act under the Industrial Hemp Regulations
8016-24-8; 89958-21-4 Cannabis sativa seed oil; Hemp seed oil; Hydrolyzed Hemp seed protein Cosmetics must not contain an isolated or concentrated phytocannabinoid or a synthetic duplicate of that phytocannabinoid 10 µg/g THC (delta-9-tetrahydrocannabinol), as per the Industrial Hemp Regulations.  
Catalase 9001-05-2       "This product is not intended for use on broken or abraded skin."
Chlorhexidine and its salts
  • 55-56-1;
  • 56-95-1;
  • 18472-51-0;
  • 3697-42-5
     a) 0.14% calculated as chlorhexidine free base  
b) 0.19% calculated as chlorhexidine diacetate
c) 0.20% calculated as chlorhexidine digluconate
d) 0.16% calculated as chlorhexidine dihydrochloride
Cholecalciferol 67-97-0 Vitamin D3 Average daily absorption must be equal to or less than 25 µg per day.    
Citric acid 77-92-9   See "Alpha-hydroxy acids".    
Citrus reticulata leaf oil 8014-17-3   a) Leave-on products 0.1%  
b) Rinse off products    
Coal tar dye
  • 95-70-5;
  • 615-50-9
  • Toluene-2,5-diamine;
  • Toluene-2,5-diamine sulfate;

See also “p-Phenylenediamine and its salts”

a) Not permitted in the area of the eye as indicated in section 14 of the Cosmetic Regulations.    
b) In hair dyes as indicated in section 22 of the Cosmetic Regulations.  

On the inner label and the outer label of the cosmetic: "CAUTION: this product contains ingredients that may cause skin irritation on certain individuals and a preliminary test according to accompanying directions should first be made. This product must not be used for dying the eyelashes or eyebrows. To do so may cause blindness."

Instructions to the following effect accompany each package of hair dye:

  • The preparation may cause serious inflammation of the skin in some persons, and a preliminary test should always be carried out to determine whether or not special sensitivity exists; and
  • To make the test, a small area of skin behind the ear or on the inner surface of the forearm should be cleansed, using either soap and water or alcohol, and a small quantity of the hair dye, as prepared for use, should be applied to the area and allowed to dry. After 24 hours, the area should be washed gently with soap and water. If no irritation or inflammation is apparent, it is usually assumed that no hypersensitivity to the dye exists. The test should, however, be carried out before each application. On no account should the hair dye be used for dyeing eyebrows or eyelashes as severe inflammation of the eye or even blindness may result."
Cyanoacrylate-based adhesives
  • 7085-85-0;
  • 137-05-3;
  • 10586-17-1
  • Ethyl cyanoacrylate;
  • Methyl cyanoacrylate;
  • Isopropyl cyanoacrylate
 a) Cyanoacrylate adhesives for eyelash extensions must be sold for professional use only (i.e., not for direct sale to consumers).   a) "For application by trained professionals only" and "Ensure the eye is protected and immobilized during application."
"WARNING. BONDS SKIN INSTANTLY. AVOID CONTACT WITH EYES, MOUTH AND SKIN. KEEP AWAY FROM CHILDREN. Eyelid bonding: consult a physician. Skin bonding: soak and ease apart gently."
b) Other cosmetics b) "WARNING. BONDS SKIN INSTANTLY. AVOID CONTACT WITH EYES, MOUTH AND SKIN. KEEP AWAY FROM CHILDREN. Eyelid bonding: consult a physician. Skin bonding: soak and ease apart gently. Not for use in the area of the eye."
Diethylene glycol 111-46-6 DEG Not permitted in oral or leave-on products (see also "Glycerin").    
Diethylhexyl Adipate 103-23-1
  • DEHA;
  • Dioctyl Adipate;
  • Bis(2-Ethylhexyl)Hexanedioate
 a) Leave-on body moisturizers a) 6.0%  
b) Other cosmetics  
Dihydrocoumarin 119-84-6   a) Leave-on products 0.035%  
b) Rinse-off products 3.5%
Ergocalciferol 50-14-6 Vitamin D2 Average daily absorption should be equal to or less than 25 µg per day.    
Ethylhexyl Ethylhexanoate 7425-14-1 2-Ethylhexyl-2-ethylhexanoate
a) Body lotion 0.1%  
b) Foot lotion 0.5%
c) Face make-up 0.6%
Ethyl methacrylate 97-63-2       "Avoid skin contact."
Eucalyptus oil
  • 8000-48-4;
  • 85203-56-1;
  • 1627700-32-6;
  • 91771-69-6;
  • 90028-48-1
  • Eucalyptus Globulus Leaf Oil;
  • Eucalyptus Citriodora Oil;
  • Eucalyptus Radiata Leaf/Stem Oil;
  • Eucalyptus Staigeriana Branch/Leaf Oil;
  • Eucalyptus Dives Leaf/Twig Oil
a) Cosmetics in solid forms    
b) Cosmetics in other forms with greater than 0.022%   b) "Keep out of reach of children", and "In case of accidental ingestion, call a Poison Control Centre or doctor immediately and advise them this product contains eucalyptus oil."
c) Cosmetics in other forms with less than or equal to 0.022%    
Fluoride containing substances
  • 16984-48-8;
  • 1333-83-1;
  • 7681-49-4;
  • 7789-75-5;
  • 7783-47-3;
  • 10163-15-2
  • Sodium fluoride;
  • Calcium fluoride;
  • Stannous fluoride;
  • Sodium monofluorophosphate
 a) Not permitted in oral products.    
b) other products    
Formaldehyde 50-00-0   a) Not permitted in aerosol products.    
b) Non-aerosol products that release formaldehyde vapours when used according to directions. b) 0.01%  
c) Oral products c) 0.1%  
d) Non-oral products as a preservative d) 0.2%  
e) Nail hardeners, must be sold with nail shields and directions for use. e) 5.0% e) "This product contains formaldehyde which has the potential to cause skin sensitivity."
Furocoumarins, except for naturally occurring in plant extracts 66-97-7   Sun tanning products 1 mg/kg (1 ppm)  
Glycerin 56-81-5   Manufacturers of oral and leave-on products containing glycerin must ensure the raw material used is within the specifications of an accepted pharmacopoeia with respect to diethylene glycol (DEG) impurities (e.g. Glycerin Official Monograph in the most current edition of the USP).    
Glycolic acid 79-14-1   See "Alpha-hydroxy acids".    
Human origin, substance of 73049-73-7
  • Human placental extracts;
  • Human placental enzymes;
  • Human placental lipids;
  • Human placental protein;
  • Human umbilical extract;
  • Hydrolyzed human placental protein;
  • Hydrolyzed keratin from human hair;
  • Lyophilized human placental extract

Manufacturers using substances of human origin must provide the following information to Health Canada:

  1. Source of the substance;
  2. A description of the method of production;
  3. Quality control data, particularly those relating to microbial limits (including viruses) and the absence of estrogenic substances;
  4. Product labelling.
    
Hydrogen peroxide 7722-84-1   See "Peroxide and peroxide-generating compounds".    
Hydroquinone 123-31-9   a) Oxidizing colouring agent for hair dyes a) 0.3% a) "Contains hydroquinone.";
"Do not use to dye eyelashes or eyebrows.";
"Rinse eyes immediately if the product comes into contact with eyes."
b) Two-component (acrylic) artificial nail systems (after mixing for use) b) 0.02% b) "Avoid skin contact.";
"Read directions carefully before using."
c) Cyanoacrylate adhesive products c) 0.1% c) "Avoid skin contact.";
"Read directions carefully before using."
Isobutane 75-28-5     0.1% w/w of 1,3-butadiene (106-99-0)  
Keratin     See "Human origin, substances of".    
Lactic acid 50-21-5   See "Alpha-hydroxy acids".    
Magnesium peroxide 1335-26-8   See "Peroxide and peroxide-generating compounds".    
Methacrylic acid 79-41-4   a) Cosmetics that contain more than 5% methacrylic acid   a) "This product contains methacrylic acid, is poisonous, is to be kept out of reach of children" and,
"In the case of accidental ingestion, a Poison Control Centre or physician is to be contacted immediately."
b) Other cosmetics  
Methoxyisopropanol 107-98-2 Propylene glycol monomethyl ether   0.5% of 2-methoxypropanol (1589-47-5)  
Methoxyisopropyl acetate
  • 108-65-6;
  • 84540-57-8
 Propylene glycol monomethyl ether acetate.   0.5% total of 2-methoxypropanol (1589-47-5) and/or 2-methoxypropyl-1-acetate (70657-70-4)  
Methyl alcohol 67-56-1 Methanol

Cosmetics containing an amount of methyl alcohol equal to or greater than 5 ml must be packaged in a child-resistant container.

Containers, that contain an amount of methyl alcohol equal or greater than 5 mL must meet the requirements set out in subsection 28.2 of the Cosmetic Regulations.

    
Methyl eugenol 93-15-2   Permitted as a naturally occurring component in botanical extracts.    
a) Fine fragrances a) 0.01%
b) Eau de toilette b) 0.004%
c) In a fragrance cream c) 0.002%
d) Other leave-on products and in oral hygiene products d) 0.0002%
e) Rinse-off products e) 0.001%
Methyl N-methyl anthranilate 85-91-6     0.1%  
Methyl salicylate 119-36-8     1%  
Methylene chloride 75-09-2 Dichloromethane Not permitted in aerosol products.    
Methylene Glycol 463-57-0   See "Formaldehyde".    
Methylisothiazolinone (MI) 2682-20-4   a) Not permitted in leave-on products.    
 

b) Rinse-off products

Note: If MI is present in a formulation with Methylisothiazolinone / Methylchloroisothiazolinone (MI/MCI) in combination, the cumulative, total concentration of MI and MI/MCI may not exceed 0.0015%.

 b) 0.0015%  
Methylisothiazolinone / Methylchloroisothiazolinone, in combination
  • 26172-55-4;
  • 2682-20-4
   a) Not permitted in leave-on products.    
 

b) Rinse-off products

Note:
MCI is only permitted when present in combination with MI.

If MI/MCI is present in a formulation with MI alone, the cumulative, total concentration of MI/MCI and MI may not exceed 0.0015%.

 b) 0.0015%  
Peroxide and peroxide-generating compounds
  • 124-43-6;
  • 1305-79-9;
  • 7722-84-1;
  • 1335-26-8;
  • 7632-04-4;
  • 1314-22-3
  • Urea peroxide;
  • calcium peroxide;
  • calcium dioxide;
  • hydrogen peroxide;
  • magnesium peroxide;
  • sodium perborate;
  • zinc peroxide

Oral products containing peroxides or peroxide-generating compounds:

Manufacturers should have the following information on hand as it may be requested by Health Canada:

  1. A laboratory report providing pH of the product as applied to tooth or teeth. Section 13 of the Cosmetic Regulations requires that the pH is greater than or equal to 4.0
  2. Product labelling indicating the directions of use and cautionary statements.
  3. If an oral cosmetic contains more than 3% hydrogen peroxide (or equivalent), notifiers must submit a clinical study to demonstrate the salivary peroxide levels do not exceed 3% during the use of the product as per the directions of use.

NB: Be aware of the conversion factor between hydrogen peroxide and other peroxide-generating compounds. For example, 10% carbamide (urea) peroxide is approximately equivalent to 3% hydrogen peroxide.

  

"If irritation (such as redness, swelling, soreness) of the gums or the mouth occurs, discontinue use and consult an oral health professional."

"Products containing peroxides are not recommended for use by children under 12 years of age."

"Consult your oral health professional before prolonged use of this product."

"Avoid swallowing the cosmetic or part thereof."

"Avoid contact of the product with the eye."

"Avoid direct contact of the active surface of the tooth whitening product with the gums and/or salivary flow."
p-Hydroxyanisole 150-76-5 4-methoxyphenol Permitted only in nail products. 0.1% "Avoid skin contact",
"Read directions carefully before using."
Pigment Red 4 2814-77-9
  • Red 36;
  • CI 12085
   3%  
Placental extracts     See "Human origin, substances of" and/or "Bovine tissues and ingredients".    
p-Phenylenediamine and its salts
  • 106-50-3;
  • 624-18-0;
  • 16245-77-5
 p-Phenylenediamine HCL;
p-Phenylenediamine sulfate

a) Not permitted in products intended for use on the skin.

Additionally see "Coal tar dye".

   
b) Oxidative hair dyes b) 3% after dilution with an oxidizer b) On the inner label and the outer label of the cosmetic:

"CAUTION:
This product contains ingredients that may cause skin irritation on certain individuals and a preliminary test according to accompanying directions should first be made. This product must not be used for dying the eyelashes or eyebrows. To do so may cause blindness."

Instructions to the following effect accompany each package of hair dye:

  1. the preparation may cause serious inflammation of the skin in some persons and a preliminary test should always be carried out to determine whether or not special sensitivity exists; and
  2. to make the test, a small area of skin behind the ear or on the inner surface of the forearm should be cleansed, using either soap and water or alcohol, and a small quantity of the hair dye as prepared for use should be applied to the area and allowed to dry. After 24 hours, the area should be washed gently with soap and water. If no irritation or inflammation is apparent, it is usually assumed that no hypersensitivity to the dye exists. The test should, however, be carried out before each application. On no account should the hair dye be used for dyeing eyebrows or eyelashes as severe inflammation of the eye or even blindness may result.
Resorcinol 108-46-3   Not permitted in cosmetics intended for use on the skin. Additionally see "Coal tar dye."    
Retinol and its esters
  • 68-26-8;
  • 127-47-9;
  • 79-81-2
  • Vitamin A;
  • Retinyl acetate;
  • Retinyl palmitate
  
  • 1.0% retinol equivalents;
  • 1.15% w/w retinyl acetate;
  • 1.83% w/w retinyl palmitate.
  
Salicylic acid 69-72-7     2%  
Silver and its salts 7440-22-4 Colloidal Silver a) Mouthwashes a) 0.04%

"This product contains silver and/or silver salts."

"Avoid contact with broken or abraded skin."
b) Other cosmetics  
Sodium borate 1303-96-4
  • Borax;
  • Sodium tetraborate
 See "Boric acid and its salts".    
Sodium perborate 7632-04-4  

See "Peroxide and peroxide-generating compounds" for oral products.

See "Boric acid and its salts" for other cosmetics.

    
Sodium picramate 831-52-7     0.1%  
Solvent Red 23 85-86-9
  • CI 26100;
  • Red No. 225;
  • Tetrazobenzene-beta-Naphthol;
  • Sudan Red BK;
  • 2-Naphthalenol, 1-[[4-(Phenylazo)Phenyl]Azo]-;
  • D&C Red no. 17;
  • Red 17;
  • Toney Red;
  • Sudan III
 a) Not permitted in cosmetics intended to be used on or around mucosal membranes such as eyes, nose or mouth. Additionally see "Coal tar dye".    
b) Hair dye product b) "Do not use to dye eyelashes or eyebrows."
"Do not use in or around the area of the eye, mouth or nose."
c) Other cosmetics c) "Do not use in or around the area of the eye, mouth or nose."
Strontium and its salts, other than nitrite 7440-24-6   a) Not permitted in aerosol products.    
b) Depilatory products b) 3.5% strontium  
c) Other cosmetics c) 6.6% in salt, or 2.1% elemental strontium, whichever represents the smallest amount of strontium (depending on the salt).  
Tagetes oil and absolute 8016-84-0   a) Leave-on products a) 0.01%  
b) Other cosmetics  
Talc     a) Products in powder form intended for infants and children   a) "Keep out of reach of children", "Keep powder away from child's face to avoid inhalation which can cause breathing problems."
b) Other cosmetics  
TBHQ 1948-33-0 t-butylhydroquinone   0.1%  
Thioglycolic acid and its salts 68-11-1   a) Eyelash curling products a) 11% (as thioglycolic acid) with a pH less than or equal to 9.5 a) "For professional use only.", "Avoid direct skin contact, wear suitable gloves.", "Avoid contact with eyes and, in the event of contact with eyes, rinse immediately with plenty of water and seek medical attention."
b) Hair dyes, waving or straightening products b) 8% (as thioglycolic acid) with a pH less than or equal to  9.5 b)"Avoid direct skin contact, wear suitable gloves.", "Not for use in the area of the eye."
c) Hair dyes, waving or straightening products for professional use c) 11% (as thioglycolic acid)  with a pH less than or equal to 9.5 c) "For professional use only."
"Avoid direct skin contact, wear suitable gloves.", "Not for use in the area of the eye."
d) Depilatory products d) 5% (as thioglycolic acid) with a pH less than or equal to 12.7 d) "Avoid contact with eyes and, in the event of contact with eyes, rinse immediately with plenty of water and seek medical attention."
Thiurams 97-77-8; 137-26-8 Disulfiram; Thiram Latex products 14%  
Triclosan 3380-34-5   a) Mouthwashes a) 0.03% a) "Avoid swallowing."
"The product is not to be used by children under the age of 12."
b) Other cosmetics b) 0.3%  

c) All oral products must meet the following conditions:

Manufacturers must ensure that polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF) impurities must not be present in quantities that exceed:

  1. 0,1 ng/g 2,3,7,8-tetra-chlorodibenzo-p-dioxin and 2,3,7,8-tetra-chlorodibenzofuran.
  2. 10 µg/g total other PCDD/PCDF impurities, with no individual impurity greater than 5 µg/g.

Manufacturers must possess the following:

  1. Raw material specifications for triclosan;
  2. Identification of the method of analysis used to determine the levels of PCDDs and PCDFs in triclosan;
  3. Finished product specifications.
   c) "Avoid swallowing."
"The product is not to be used by children under the age of 12."
Urea 57-13-6   a) Cosmetics intended to be diluted in bath water    
b) Other cosmetics b) 10%
Urea (carbamide) peroxide 124-43-6   See "Peroxide and peroxide-generating compounds".    
Zinc peroxide 1314-22-3   See "Peroxide and peroxide-generating compounds".    
Zirconium and its compounds 7440-67-7   Not permitted in aerosol dispensers.    
Permitted as aluminum zirconium complexes and as zirconium lakes, salts and pigments of colouring agents only. See also "Aluminum zirconium complexes".

Table 2 notes

Table 2 note 1

Cells in this column are left blank when the substance does not have a known CAS.

Return to table 2 note 1 referrer

Table 2 note 2

Cells in this column are left blank when no synonyms or related compounds are provided for the entry.

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Table 2 note 3

Cells in this column are left blank when no condition of use is specified and the restriction applies to all cosmetic products.

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Table 2 note 4

Cells in this column are left blank when no maximum concentration is specified.

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Table 2 note 5

Cells in this column are left blank when no warning or cautionary statements are specified.

Return to table 2 note 5 referrer

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